Integrative approach to HPA Axis Dysfunction (Adrenal Fatigue)
HPA axis dysregulation presents as fatigue, sleep disruption, mood instability, and poor stress resilience. While "adrenal fatigue" is not an ICD diagnosis, the clinical pattern of blunted cortisol rhythm is real and measurable.
Evidence highlight
Rhodiola rosea (400mg/day) significantly reduces burnout-related fatigue and cortisol awakening response dysregulation in clinical trials — Grade B evidence for HPA axis support.
Commonly used supplements
- Ashwagandha
- Rhodiola rosea
- Holy basil (Tulsi)
- Vitamin C
- Pantothenic acid (B5)
- Magnesium glycinate
- Licorice root
- Phosphatidylserine
Key interaction flags
Licorice root + antihypertensives or diuretics
Rhodiola + SSRIs (serotonergic risk)
Phosphatidylserine + anticoagulants
Ashwagandha + thyroid medications
Labs to consider
Clinical note
The 4-point salivary cortisol pattern determines the protocol direction. High evening cortisol needs phosphatidylserine. Low morning cortisol needs adaptogenic support. Treating without pattern data often produces inconsistent results.
Build a complete HPA Axis Dysfunction (Adrenal Fatigue) protocol in under 8 minutes
Describe your patient's case. ClarityTx synthesizes from 3,000+ clinician-reviewed monographs and checks all drug-supplement interactions automatically.
Evidence-graded supplements
Every supplement recommendation for HPA Axis Dysfunction (Adrenal Fatigue) carries an A-D evidence grade with a link to the source. You see exactly what the evidence shows before you prescribe.
Automatic interaction checking
ClarityTx checks the full HPA Axis Dysfunction (Adrenal Fatigue) protocol against the patient's medication list. Severity rated: Contraindicated, Avoid, Monitor, or Caution.
Patient-ready in one click
Switch to patient view: plain-language instructions, dosing schedule, and a 7-day meal plan. Export to PDF or share directly. No PHI stored.
Your first HPA Axis Dysfunction (Adrenal Fatigue) protocol is free
No credit card. No setup. Describe the patient case and see a full, evidence-graded protocol in under 8 minutes.
Build your first protocol freeRelated conditions
Key supplements for HPA Axis Dysfunction (Adrenal Fatigue)
Elevate Your Practice: Simplify Workflow & Strengthen Patient Care
- Create personalized, evidence-based protocols faster and smarter, freeing you to focus on what matters most: your patients.
- Save hours of research time daily by accessing thousands of research articles and peer-reviewed medical journals in one centralized database.
- Ensure safer, more effective patient outcomes with consistently updated, reliable information at your fingertips.
