Evidence-first writing for integrative clinicians
Drug-nutrient interactions, protocol reviews, research digests — written for the point of care, not the press release.
The Hidden Risks in Supplement Recommendations: What Every Clinician Should Know
Patients arrive with self-assembled supplement stacks and strong opinions about what they need. Understanding where interaction risk hides — and how to review it efficiently — is one of the more important skills in integrative practice.
ClarityTx evidence grading — every claim in every article links to its grade.
How to Create a Patient-Ready Protocol Without a Staff of Researchers
Small integrative practices can't afford hours of after-hours research per patient. Here's how to build evidence-based, personalized protocols that patients can actually follow -- without a full research team behind you.
Not All Clinical AI Is the Same: What Integrative Clinicians Should Look for in AI Tools
General-purpose AI was not designed for integrative medicine. Knowing what to look for -- reviewed sources, interaction checking, evidence grading -- separates tools that help from tools that create new risks.
Urolithin A: Why Your Patient's Gut Microbiome Determines Whether Pomegranate Works
Urolithin A induces mitophagy via the PINK1/Parkin pathway — but only ~40% of people can produce it from dietary ellagitannins. The Phase 2 RCT shows what supplemental UA does to mitochondrial function in skeletal muscle, regardless of microbiome status.
Spermidine: The Autophagy Inducer That Declines With Age
Serum spermidine falls ~50% between age 20 and 80. New evidence links dietary and supplemental spermidine to autophagy induction, cardiovascular protection, and memory preservation — through a mechanism entirely independent of mTOR.
Berberine vs. Metformin: What the Evidence Actually Says
Multiple RCTs show berberine matches metformin on HbA1c reduction in T2DM. Here is what the trials looked like, where the gaps are, and how to think about it at the point of care.
Low-Dose Naltrexone: The Off-Label Use the Evidence Is Finally Catching Up To
At 1 to 4.5mg per day, naltrexone does something pharmacologically distinct from its standard addiction-medicine dose. Growing evidence supports its use in fibromyalgia, Crohn's disease, and MS via a non-opioid neuroinflammatory mechanism.
Akkermansia muciniphila: The Gut Bacterium Rewriting Metabolic Medicine
Akkermansia muciniphila inversely correlates with obesity, T2DM, and metabolic syndrome in virtually every human cohort studied. The first human RCTs show what supplementation actually does — and why the mechanism matters for integrative protocols.
CoQ10 Depletion from Statins: The Numbers, the Evidence, the Protocol
Atorvastatin reduces plasma CoQ10 by 40–50% within 30 days. We break down the mechanism, the clinical significance, and what a defensible repletion protocol looks like.
Magnesium Forms: Why the Form Matters More Than the Dose
Glycinate, threonate, malate, oxide — each behaves differently in the body. A practical guide to matching form to indication, with absorption data and clinical use cases.
Vitamin D Loading Doses: Evidence Review for Clinical Practice
Loading protocols achieve target 25(OH)D levels faster — but the evidence on which protocol, and in which patients, is more nuanced than guidelines suggest.
Ashwagandha for HPA Axis Regulation: What the Trials Actually Show
Six RCTs, three dosing protocols, two extract standards. We map the heterogeneity and pull out what is actually reproducible for clinical use.
What Makes a Protocol Defensible? Evidence Grading in Practice
A protocol is only as strong as its citations. We walk through how ClarityTx grades evidence — and why the grade matters more than the study count.
Probiotics for Anxiety: Reading the Gut-Brain Axis Trials Carefully
The gut-brain connection is real — but the clinical evidence for specific probiotic strains in anxiety is messier than headlines suggest. Here is the honest read.
Iron Infusion vs. Oral Supplementation: A Clinical Decision Framework
Oral iron fails in a predictable set of patients. We define the clinical signals that should push you toward IV iron earlier, with GI tolerability and absorption data.
The 12 Drug-Nutrient Depletions Most Clinicians Miss
PPIs and B12. Statins and CoQ10. Metformin and folate. A structured reference covering the most clinically significant depletions, with repletion ranges.
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