Evidence-first writing for integrative clinicians
Drug-nutrient interactions, protocol reviews, research digests — written for the point of care, not the press release.
Why Integrative Clinicians Need Decision Support That Thinks the Way They Do
Conventional clinical decision tools were built for conventional medicine. They flag drug-drug interactions but miss drug-nutrient depletions. The gap is structural — and it is costing clinicians time, confidence, and patients.
ClarityTx evidence grading — every claim in every article links to its grade.
Berberine vs. Metformin: What the Evidence Actually Says
Multiple RCTs show berberine matches metformin on HbA1c reduction in T2DM. Here is what the trials looked like, where the gaps are, and how to think about it at the point of care.
CoQ10 Depletion from Statins: The Numbers, the Evidence, the Protocol
Atorvastatin reduces plasma CoQ10 by 40–50% within 30 days. We break down the mechanism, the clinical significance, and what a defensible repletion protocol looks like.
Magnesium Forms: Why the Form Matters More Than the Dose
Glycinate, threonate, malate, oxide — each behaves differently in the body. A practical guide to matching form to indication, with absorption data and clinical use cases.
Vitamin D Loading Doses: Evidence Review for Clinical Practice
Loading protocols achieve target 25(OH)D levels faster — but the evidence on which protocol, and in which patients, is more nuanced than guidelines suggest.
Ashwagandha for HPA Axis Regulation: What the Trials Actually Show
Six RCTs, three dosing protocols, two extract standards. We map the heterogeneity and pull out what is actually reproducible for clinical use.
What Makes a Protocol Defensible? Evidence Grading in Practice
A protocol is only as strong as its citations. We walk through how ClarityTx grades evidence — and why the grade matters more than the study count.
Probiotics for Anxiety: Reading the Gut-Brain Axis Trials Carefully
The gut-brain connection is real — but the clinical evidence for specific probiotic strains in anxiety is messier than headlines suggest. Here is the honest read.
Iron Infusion vs. Oral Supplementation: A Clinical Decision Framework
Oral iron fails in a predictable set of patients. We define the clinical signals that should push you toward IV iron earlier, with GI tolerability and absorption data.
The 12 Drug-Nutrient Depletions Most Clinicians Miss
PPIs and B12. Statins and CoQ10. Metformin and folate. A structured reference covering the most clinically significant depletions, with repletion ranges.
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