Integrative approach to Irritable Bowel Syndrome (IBS)
IBS affects 10-15% of the population and involves gut-brain axis dysregulation, microbiome imbalance, and visceral hypersensitivity. Integrative protocols address the underlying physiology rather than symptoms alone.
Evidence highlight
Enteric-coated peppermint oil (187mg TID) reduces global IBS symptoms by 40% vs placebo in meta-analysis of 6 RCTs — Grade A evidence.
Commonly used supplements
- Peppermint oil (enteric-coated)
- Probiotics (strain-specific)
- L-glutamine
- Psyllium husk
- Berberine (IBS-D)
- Slippery elm
- Zinc carnosine
- Digestive enzymes
Key interaction flags
Peppermint oil + acid suppression medications
High-dose probiotics + immunosuppressants
Berberine + CYP3A4 substrates
Labs to consider
Clinical note
IBS-D and IBS-C respond to different interventions. Protocol design should start with subtype identification, then layer in gut-brain axis support (often overlooked) alongside the microbiome work.
Build a complete Irritable Bowel Syndrome (IBS) protocol with Clarity
Describe your patient's case. ClarityTx synthesizes from 3,000+ clinician-reviewed monographs and checks all drug-supplement interactions automatically.
Evidence-graded supplements
Every supplement recommendation for Irritable Bowel Syndrome (IBS) carries an A-D evidence grade with a link to the source. You see exactly what the evidence shows before you prescribe.
Automatic interaction checking
ClarityTx checks the full Irritable Bowel Syndrome (IBS) protocol against the patient's medication list. Severity rated: Contraindicated, Avoid, Monitor, or Caution.
Patient-ready in one click
Switch to patient view: plain-language instructions, dosing schedule, and a 7-day meal plan. Export to PDF or share directly. Use de-identified clinical information.
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