Integrative approach to Migraine
Migraine affects 15% of the population and is significantly undertreated. Integrative approaches address mitochondrial dysfunction, magnesium deficiency, neuroinflammation, and hormonal triggers — reducing frequency and severity alongside conventional prophylaxis.
Evidence highlight
Magnesium (400-600mg/day) reduces migraine frequency by 41% vs 15% placebo in double-blind RCT — Grade A prophylactic evidence. Up to 50% of migraine patients have interictal magnesium deficiency undetectable by serum testing.
Commonly used supplements
- Magnesium glycinate
- Riboflavin (B2)
- CoQ10 (ubiquinol)
- Butterbur (PA-free)
- Feverfew
- Melatonin
- Omega-3s
- 5-HTP
Key interaction flags
Butterbur + hepatotoxic medications (monitor LFTs)
5-HTP + triptans or SSRIs (serotonin syndrome risk)
Feverfew + anticoagulants
High-dose riboflavin + certain chemotherapy agents
Labs to consider
Clinical note
RBC magnesium is the only reliable test for intracellular magnesium status — serum magnesium is normal even in deficiency. Migraine prophylaxis with riboflavin (400mg/day) + CoQ10 (300mg/day) + magnesium has additive benefit and is supported by the Canadian Headache Society.
Build a complete Migraine protocol in under 8 minutes
Describe your patient's case. ClarityTx synthesizes from 3,000+ clinician-reviewed monographs and checks all drug-supplement interactions automatically.
Evidence-graded supplements
Every supplement recommendation for Migraine carries an A-D evidence grade with a link to the source. You see exactly what the evidence shows before you prescribe.
Automatic interaction checking
ClarityTx checks the full Migraine protocol against the patient's medication list. Severity rated: Contraindicated, Avoid, Monitor, or Caution.
Patient-ready in one click
Switch to patient view: plain-language instructions, dosing schedule, and a 7-day meal plan. Export to PDF or share directly. No PHI stored.
Your first Migraine protocol is free
No credit card. No setup. Describe the patient case and see a full, evidence-graded protocol in under 8 minutes.
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Key supplements for Migraine
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