Creatine Isn't Just for Athletes. The Brain Evidence Is Compelling.
Your patients are already reading about creatine for depression and cognitive decline. Here's the full clinical picture — evidence-graded, dosed, and integrated into a complete protocol you can use today.
By Keith Berkowitz, MD
Board-Certified Internist · Integrative & Functional Medicine
2 free protocols · no credit card · no expiry
Evidence snapshot
Three studies clinicians can inspect quickly
Review
Creatine for the Treatment of Depression
A focused review of the brain-energy rationale and early clinical signal for creatine in depressive disorders.
RCT
Creatine + SSRI augmentation
An 8-week double-blind trial studied creatine 5 g/day added to escitalopram in women with major depressive disorder.
Dose finding
Adjunct dosing in resistant depression
A pilot study evaluated 5 g/day and 10 g/day as adjunctive treatment in major depression.
Clinical guardrails included
The protocol includes nuance, not just a supplement name.
Renal function/eGFR, hydration status, and nephrotoxic medication context
Bipolar spectrum, hypomania/mania history, activation, and insomnia escalation
Pregnancy/lactation uncertainty and individualized risk-benefit review
GI tolerance, dose form, medication context, and follow-up response tracking
Inside the protocol
What a complete creatine protocol looks like
ClarityTx builds the full integrated picture: supplements with grades, dosing, mechanisms, interactions, and cited studies.
Supplements tab — every recommendation graded by clinical evidence. Creatine: Grade A, 5–10g daily.
Full protocol overview with safety score, timeline, and 19 recommendations
11 cited studies, 5 driving mechanisms, full mechanism of action
Medicinal foods, lifestyle, and adjunct recommendations — all evidence-graded
What your patients receive
One click to a shareable patient plan
The clinician view and the patient view are separate. Clinicians see the evidence and mechanisms. Patients get a clean, readable plan they can actually follow.
Patient Plan view — clean, readable, no clinical jargon. Exportable as PDF or Word doc.
View the protocolWhy it works
Three driving mechanisms the evidence supports
Mitochondrial energy support
Creatine replenishes phosphocreatine in neurons, restoring ATP availability in energy-deficient brain states — a key driver in depression and cognitive fatigue.
Oxidative stress reduction
Direct antioxidant activity and upregulation of cellular defence pathways reduce neuroinflammatory burden linked to mood and memory decline.
Neurotransmitter modulation
Improves glutamate/GABA balance and serotonin precursor availability, with particular relevance to treatment-resistant depression and Long COVID brain fog.
ClarityTx surfaces all of this automatically.
Type the case. Get the full protocol, graded, dosed, cited.
What ClarityTx builds for you
Not just creatine. The complete picture.
Describe any patient case and ClarityTx returns a full integrated protocol in minutes.
Built by clinicians
The AI is the speed. The knowledge is human.
Every monograph in ClarityTx is reviewed by our clinical team of MDs, NDs, and PharmDs before it goes live.
“PCOS, perimenopause, thyroid, adrenal: these cases are complex and the research moves fast. ClarityTx keeps me current without hours on PubMed. My patients notice.”
Dr. Mimosa Tonnu, ND
Hormonal & Cardiometabolic Medicine
“In 16 years of global practice, I have never encountered a platform quite like ClarityTx. It brings together botanical medicine, diagnostics, and diet with the pathophysiology and scientific references behind every recommendation.”
Dr. Todd Born, ND, CNS
Integrative Medicine · Gig Harbor, WA
“I use it in my own practice and recommend it to every practitioner I train. The evidence grading alone saves hours of research every week.”
Dr. Sydney Sharaf, ND
Integrative Oncology & Medical Nutrition
Try it free
Build the creatine protocol yourself — in minutes.
Type your patient case. ClarityTx builds the full evidence-based protocol, graded and cited. Creatine, plus every other relevant intervention.
2 complete protocols free · No credit card · No expiry